Four Cytotoxic N4-Substituted Thiosemicarbazones Derived from 2-Hydroxynaphthalene-1-carboxaldehyde
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چکیده
منابع مشابه
The Carcinostatic Activity of ^-(A^-Heterocyclic Carboxaldehyde Thiosemicarbazones II. 3-Hydroxypyridine-2-carboxaldehyde Thiosemicarbazone1
3-Hydroxypy rid ine-2-carboxaldehyf le thiosemicarbazone (3-HP) has been shown to be active against leukemia L1210, Ehrlich ascites carcinoma, lym]>homa L5178Y, the Lewis lung carcinoma, and adenocarcinoma 755. 3-HP is active, in some in stances, by gavage and also by delayed treatment. 3-HP is a member of a broad class of a-(.Y)-heterocyclic carboxaldehyde thiosemicarbazones, several of which ...
متن کاملThe carcinostatic activity of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones. II. 3-Hydroxypyridine-2-carboxaldehyde thiosemicarbazone.
3-Hydroxypy rid ine-2-carboxaldehyf le thiosemicarbazone (3-HP) has been shown to be active against leukemia L1210, Ehrlich ascites carcinoma, lym]>homa L5178Y, the Lewis lung carcinoma, and adenocarcinoma 755. 3-HP is active, in some in stances, by gavage and also by delayed treatment. 3-HP is a member of a broad class of a-(.Y)-heterocyclic carboxaldehyde thiosemicarbazones, several of which ...
متن کاملInhibition of deoxyribonucleotide synthesis by pyridine carboxaldehyde thiosemicarbazones.
inhibited mammalian ribonucleoside diphosphate reductase in vitro. The inhibition was partially reversed by increasing the concentration of the dithiol substrate, but not of ferrous ion, magnesium ion, nucleotide substrate, or allosteric activator. Increasing the concentration of ferrous ion resulted in greater enzymic inhibition, a finding that is consistent with a model in which either the ac...
متن کاملAntibacterial and herbicidal activity of ring-substituted 2-hydroxynaphthalene-1-carboxanilides.
In this study, a series of twenty-two ring-substituted 2-hydroxynaphthalene-1‑carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistant S. aureus strains, Mycobacterium marinum, M. kasasii, M. smegmatis. and M. avium paratuberculosis. The compounds were also tested for their ac...
متن کاملAntimycobacterial and herbicidal activity of ring-substituted 1-hydroxynaphthalene-2-carboxanilides.
In this study, a series of 22 ring-substituted 1-hydroxynaphthalene-2-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Mycobacterium marinum, Mycobacterium kansasii and Mycobacterium smegmatis. The compounds were also tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach ...
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ژورنال
عنوان ژورنال: ChemInform
سال: 2004
ISSN: 0931-7597,1522-2667
DOI: 10.1002/chin.200409020